Chemoreactome analysis of natural and synthetic statins indicates a more favorable safety profile of monacolin K

Increasing the effectiveness and safety of pharmacotherapy hyperlipidemia is an urgent task gastroenterology cardiology. Statin drugs can differ signifi cantly not only in lipid profile normalization, but also spectrum side effects. The paper presents results a comparative chemoreactomic analysis “natural” statins (monacolins K, J, L, simvastatin) synthetic (atorvastatin, fl uvastatin). It important to note that monacolin K does cause negative metabolic changes characteristic statins. In general, assessments accumulation studied molecules various human cells tissues, effects on metabolome proteome, therapy indicate more favorable statin K.